In the 19th century, Nicolas Appert, a chemist, tuned a technique that permitted the sterilization of food. Thanks to this process, Quiberon became the leading harbour for sardine fishing and the production of canned sardines in France. Many families from the Finistère département migrated to Quiberon for the fishing season (May to October). When the men put out to sea, the women worked in the sardine can factories.

The railway between Auray and Quiberon was inaugurated in 1882. It deeply changed Quiberon's inhabitants' way of life. Fishing, canning and the exploitation of seaweed has been replaced by tourism. At that time, some famous people went to Quiberon for a stay, including the writers Gustave Flaubert and Anatole France, and the actress Sarah Bernhardt.